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Selected publications 



Van Battum EY, Brignani S, Pasterkamp RJ (2014) Axon guidance proteins in neurological disordersLancet Neurology in press.


Jongbloets BC, Pasterkamp RJ (2014) Semaphorin signaling during development. Development, in press. 


Van Battum EY, Gunput RF, Lemstra S, Groen EJ, Yu KL, Adolfs Y, Zhou Y, Hoogenraad CC, Yoshida Y, Schachner M, Akhmanova A, Pasterkamp RJ (2014) The Intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fiber connections. Nature Communications 5, 4317. 


Schmidt ERE, Brignani S, Adolfs A, Lemstra S, Demmers J, Vidaki M, Donahoo AS, Lillevälli K, Vasar E, Richards LJ, Karagogeos D, Kolk SM, Pasterkamp RJ (2014) Subdomain-Mediated Axon-Axon Signaling and Chemoattraction Cooperate to Regulate Afferent Innervation of the Lateral Habenula. Neuron 83, 372-387.    


Yau KW, van Beuningen SF, Cunha-Ferreira I, Cloin BM, van Battum EY, Will L, Schatzlw P, Tas RP, van Krugten J, Katrukha EA, Jiang K, Wulf PS, Mikhaylova M, Harterink M, Pasterkamp RK, Akhmanova A, Kapitein LC, Hoogenraad CC (2014) Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development. Neuron 82, 1058-1073.


Jaarsma D, van den Berge R, Wulf PS, van Erp S, Keijzer N, Schlager MA, de Graaf E, De Zeeuw CI, Pasterkamp RJ, Akhmanova A, Hoogenraad CC (2014) A role for Bicaudal-D2 in radial cerebellar granule cell migration. Nature Communications 5, 3411.


Van der Vaart B, Van Riel WE, Doodhi H, Kevenaar JT, Katrukha EA, Gumy L, Bouchet BP, Grigoriev I, Spangler SA, Yu KL, Wulf PS, Wu J, Lansbergen G, van Battum EY, Pasterkamp RJ, Mimori-Kiyosue Y, Demmers J, Olieric N, Maly IV, Hoogenraad CC, Akhmanova A (2013) CFEOM-1-associated KIF21A is a cortical microtubule growth inhibitor. Developmental Cell 27, 145-160.


Van den Heuvel DM, Harschnitz O, van den Berg LH, Pasterkamp RJ (2014) Taking a risk: a therapeutic focus on ataxin-2 in ALS? Trends Molecular Medicine 20, 25-35.


Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJ, Aricescu AR, Pasterkamp RJ, Siebold C (2013) Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub. Science 341, 77-80.


Groen EJ, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, van den Heuvel DM, Koppers M, van Diggelen F, van Heest J, Demmers JA, Kirby J, Shaw PJ, Aronica E, Spliet WG, Veldink JH, van den Berg LH, Pasterkamp RJ (2013) ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. Human Mol Genetics 22, 3690-3704. 


Kolodkin AL, Pasterkamp RJ (2013) SnapShot: Axon Guidance II. Cell 153, 722.


Pasterkamp RJ, Kolodkin AL (2013) SnapShot: Axon Guidance. Cell 153, 494.


Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A (2013) S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. PNAS 110, 3113-3118.


Trezza V, Damsteegt R, Manduca A, Petrosino S, Van Kerkhof LW, Pasterkamp RJ, Zhoy Y, Campolongo P, Cuomo V, Di Marzo V, Vanderschuren LJ (2012) Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats. J Neurosci 32, 14899-14908.


Pasterkamp RJ (2012) Getting neural circuits into shape with semaphorinsNature Rev Neurosci 13, 605-618.


Messina et al. (2011) Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility. Human Mol Genetics 20, 4759-4774.


Van Es MA et al. (2011) Angiogenin variants in Parkinson's disease and amyotrophic lateral sclerosis. Ann Neurology 70, 964-973.

Zhou Y, Adolfs Y, Pijnappel WWM, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ (2011) MICAL-1 is a negative regulator of MST-NDR Kinase signaling and apoptosis.. Molecular Cellular Biology 31, 3603-3615.

Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peranen J, Pasterkamp RJ, Van der Sluijs P, Hoogenraad CC, Akhmanova A 
(2011) Rab6, Rab8, and MICAL3 cooperate in controlling docking and fucsion of exocytotic carriers.Current Biology 21, 967-974.

Fenstermaker AG, Prasad AA, Bechara A, Adolfs Y, Tissir F, Goffinet A, Zou Y, Pasterkamp RJ (2010) Wnt-Planar Cell Polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J Neurosci 30, 16053-16064.

Derijck AAH, Van Erp S, Pasterkamp RJ (2010) Semaphorin signaling: Molecular switches at the midline.
Trends Cell Biol 20:568-576.

Vorstman JA, van Daalen E, Jalali GR, Schmidt ER, Pasterkamp RJ, de Jonge M, Hennekam EA, Janson E, Staal WG, van der Zwaag B, Burbach JP, Kahn RS, Emanuel BS, van Engeland H, Ophoff R (2011) A double hit implicates DIAPH3 as an autism risk gene. Mol Psychiatry 16:442-451.

K
olk SM, Gunput RA, Tran TS, Van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ (2009) Semaphorin3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci 29: 12542-12557.

Van Es MA, Veldink JH et al. (2009) Genome-wide association study identifies 19p13.3 (UNC13A) and 19p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genetics 41:1083-1087.

Pasterkamp RJ, Giger RJ (2009) Semaphorin function in neural plasticity and disease. Curr Opin Neurobiol 19: 263-274.

Zhou Y, Gunput RF, Pasterkamp RJ (2008) Semaphorin signaling: progress made and challenges ahead. Trends Biochem Sci 33, 161-170.


Suzuki K, Yamamoto M, Okuno T, Pasterkamp RJ, Takegahara N, Takamatsu H, Rennert PD, Kolodkin AL, Kumanogoh A and Kikutani H (2007) Semaphorin 7A initiates T cell-media

ted inflammatory responses through alpha1/beta11 integrin. Nature 446, 680-684.


Siebold S, Berrow N, Walter TS, Harlos K, Owens RJ, Stuart DI, Terman JR, Kolodkin AL, Pasterkamp RJ and Jones EY (2005) High-resolution structure of the catalytic region of MICAL, a multi-domain flavoenzyme signaling molecule. PNAS 102, 16836-16841.


Pasterkamp RJ (2005) R-Ras fills another GAP in Semaphorin signaling. Trends Cell Biol. 15, 61-64.


Pasterkamp RJ, Peschon JJ, Spriggs MK, and Kolodkin AL (2003) Semaphorin7A promotes axon outgrowth through integrins and MAPKs. Nature 424, 398-405 (article).


Terman JR, Mao T, Pasterkamp RJ, Yu H-H, and Kolodkin AL (2002) MICALs, a family of conserved oxidoreductases, function in plexin-mediated axonal repulsion. Cell 109, 887-900.


Pasterkamp RJ, and Kolodkin AL (2003) Semaphorin junction: making tracks toward neural connectivity. Curr Opin Neurobiol 13, 79-89.


Pasterkamp RJ, De Winter F, Holtmaat AJGD, and Verhaagen J (1998) Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons. J Neurosci 18, 9962-9976.



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